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 Science News   Show all: Science News

Long-term results of Gleevec® published

Results from a nearly 11-year follow-up study, that showed an estimated overall survival rate of 83.3 percent, have now been published by investigators. According to the National Cancer Institute, prior to Gleevec's 2001 FDA approval, fewer than one in three CML patients survived five years past diagnosis.

Neuroscientists pinpoint key gene controlling tumor growth in brain cancers

Investigators have identified a stem cell-regulating gene that affects tumor growth in patients with brain cancer and can strongly influence survival rates of patients. The findings could move physicians closer to their goal of better predicting the prognosis of patients with brain tumors and developing more personalized treatments for them.

New hope for treating heart failure

Heart failure patients who are getting by on existing drug therapies can look forward to a far more effective medicine in the next five years or so, thanks to researchers.

Promising new strategy to attack the most lethal brain tumor in children

Researchers have revealed new insight into how the most deadly pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG), may develop. They also have identified a compound that targets the "on" switch for cancer-promoting genes, which resulted in shrinking tumor size and increased survival in an animal model of DIPG. Preparations for a clinical trial are now under way.

Tackling Lupus and its renal complications with novel small molecule drug c…

A drug starting through the pipeline could ameliorate or even eliminate the symptoms in most lupus sufferers, report researchers.

World's largest autism genome database shines new light on many 'autisms'

An additional 18 gene variations have been identified that appear to increase the risk of autism. The study involved the analysis of 5,205 whole genomes from families affected by autism -- making it the largest whole genome study of autism to date.

Scientists discover metabolic pathway that drives tumor growth in aggressiv…

A rheumatoid arthritis drug can block a metabolic pathway that occurs in tumors with a common cancer-causing gene mutation, offering a new possible therapy for aggressive cancers with few therapeutic options, according to a study.

Genetic variant linked to overactive inflammatory response

Genetic variation is the reason why some immune systems overreact to viruses, researchers have discovered.

Studying genes in clusters allows for better predictions

When many genes regulate a single trait, they commonly work together in large clusters or 'networks.' Taking this into account allows better predictions of how an individual's genetic make-up affects the trait concerned. The risk of perceiving the importance of an individual gene incorrectly is also reduced. This has been shown through a detailed analysis of thousands of related yeast cells.

Alzheimer's drug prescribed off-label could pose risk for some

Donepezil, a medication that is approved to treat people with Alzheimer's disease, should not be prescribed for people with mild cognitive impairment without a genetic test. Researchers discovered that for people who carry a specific genetic variation -- the K-variant of butyrylcholinesterase, or BChE-K -- donezpezil could accelerate cognitive decline.

 Pharmacology News   Show all: Pharmacology News

Targeting cancer stem cells improves treatment effectiveness, prevents meta…

Targeting cancer stem cells may be a more effective way to overcome cancer resistance and prevent the spread of squamous cell carcinoma — the most common head and neck cancer and the second-most common skin cancer, according to a new study. Head and neck squamous cell carcinoma is a highly invasive form of cancer and frequently spreads to the cervical lymph nodes.

Malaria treatment: Soon to be simpler, more flexible, and more efficient?

Malaria infections may soon be treated much more efficiently than they are at present. Researchers have developed a novel drug release procedure for this purpose. The procedure enables the active ingredient Artemisone to be administered reliably at quantities and time intervals that are tailored exactly to the patients' individual needs.

Novel antibiotic combination therapy overcomes deadly drug-resistant bacter…

Researchers have taken a significant step toward defeating antibiotic-resistant infections by combining two different antibiotics that each block a different kind of drug-destroying enzyme secreted by bacteria.

Marijuana use associated with increased risk of stroke, heart failure

Using marijuana raises the risk of stroke and heart failure even after accounting for demographic factors, other health conditions and lifestyle risk factors such as smoking and alcohol use, according to new research.

Hard choices? Ask your brain's dopamine

Researchers have learned how dopamine governs ongoing decisions, yielding insights into Parkinson's, drug addiction.

 Industry News   Show all: Industry News

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