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 Science News   Show all: Science News

The way breast cancer genes act could predict your treatment

Effective treatment options for breast cancer can be predicted based on the way certain breast cancer genes act or express themselves, a researcher has concluded.

Genome analysis helps keep deadly brain cancer at bay for five years

An analysis of a patient’s deadly brain tumor helped doctors identify new emerging mutations and keep a 55-year old woman alive for more than five years, researchers report.

Gene variants associated with body shape increase risk of heart disease, ty…

A study has found that a pattern of gene variants associated with a body type, in which weight is deposited around the abdomen, rather than in the hips and thighs, increases the risk for type 2 diabetes and coronary heart disease, as well as the incidence of several cardiovascular risk factors. abdominal

Study of 52,000 men uncovers the genetics underlying male pattern baldness

A genomic study of baldness identified more than 200 genetic regions involved in this common but potentially embarrassing condition. These genetic variants could be used to predict a man's chance of severe hair loss.

Diabetes in your DNA? Scientists zero in on the genetic signature of risk

Many genetic mutations have been linked to type 2 diabetes, but no clear genetic signature has emerged. Now, new results may explain how multiple genetic flaws can lead to the same disease: They seem to change the way certain cells in the pancreas 'read' their genes.

New study links 'mastermind' gene to rare cancer-causing tumor

Scientists have discovered a new "mastermind fusion gene" may be associated with a rare cancer-causing tumor -- pheochromocytomas ("pheo") and paragangliomas -- according to a study. This breakthrough discovery could lead to more precise treatment as well as a better understanding of cancer itself.

Data mining tools for personalized cancer treatment

In an European lab, drug testing is done, testing various leukemia drugs with patient samples instead of the patients themselves. This enables the researchers to test different drug combinations efficiently and without burdening the patient.

High-throughput, in vivo validation of candidate congenital heart disease g…

Specific genetic errors that trigger congenital heart disease in humans can be reproduced reliably in Drosophila melanogaster -- the common fruit fly -- an initial step toward personalized therapies for patients in the future.

Scientists identify aggressive pancreatic cancer cells and their vulnerabil…

A series of preclinical experiments using patient-derived tumor xenografts (PDXs) and mouse models point to potential treatments for patients with a rapidly-progressing and resistant subgroup of tumor cells.

Genetic profiling can guide stem cell transplantation for patients with mye…

A single blood test and basic information about a patient’s medical status can indicate which patients with myelodysplastic syndrome (MDS) are likely to benefit from a stem cell transplant, according to new research.

 Pharmacology News   Show all: Pharmacology News

New tool developed to help avoid adverse drug reactions

Medicines are an important part of treating and preventing disease in adults and children. Now researchers have developed a new tool to help avoid adverse reactions to medicines.

Scientists identify chain reaction that shields breast cancer stem cells fr…

Working with human breast cancer cells and mice, researchers say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after chemotherapy.

Using a rabbit virus to treat multiple myeloma

Treating multiple myeloma (MM) with myxoma virus (MYXV) eliminated a majority of malignant cells in preclinical studies, report investigators. Furthermore, introduction of MYXV had no impact on the bone marrow compartment and elicited a strong immune response that eradicated disease in some animals.

Drugs that alter inhibitory targets offer therapeutic strategies for Autism…

Memories are formed at structures in the brain known as dendritic spines, which communicate with other brain cells through 'synapses.' Researchers recently discovered that an inhibitory brain receptor triggers synaptic pruning in adolescence. Now, a new article shows that drugs that selectively target these receptors, when administered during adolescence, can alter synapse number, with possible implications for the treatment of autism and schizophrenia.

From photosynthesis to new compounds for eye diseases

Researchers have succeeded in using X-rays to minutely observe a photosynthesis reaction and produce a movie of the event. The findings will aid understanding of similar processes in the human eye.
Biomedical engineers have created a smart, targeted drug delivery system using immune cells to attack cancers.

Researchers urge caution around psilocybin use

12/30/2016 06:06 PM - Pharmacology News -- ScienceDaily
In a survey of almost 2,000 people who said they had had a past negative experience when taking psilocybin-containing 'magic mushrooms,' a researchers say that more than 10 percent believed their worst 'bad trip' had put themselves or others in harm's way, and a substantial majority called their most distressing episode one of the top 10 biggest challenges of their lives.

Antibiotic resistance just became more complex

12/29/2016 02:19 PM - Pharmacology News -- ScienceDaily
Bacteria that are susceptible to antibiotics can survive when enough resistant cells around them are expressing an antibiotic-deactivating factor. This new take on how the microbial context can compromise antibiotic therapy was just published by a team of microbiologists.

Tracking movement of immune cells identifies key first steps in inflammator…

Using a novel approach for imaging the movement of immune cells in living animals, researchers have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.

Researchers unlock mechanism of drug resistance in aggressive breast cancer

Scientists report findings of how triple negative breast cancer cells are able to bypass treatment with trametinib, a U.S. Food and Drug Administration-approved drug that belongs to a class of commonly used anti-cancer drugs called kinase inhibitors. The researchers also reported findings from laboratory models of breast cancer testing a potential treatment approach that could prevent the onset of resistance.

Pancreatic tumors rely on signals from surrounding cells

Scientists have found that targeting the interaction between a pancreatic tumor and its microenvironment could weaken cancer.

New method could turbocharge drug discovery, protein research

A team led by scientists has developed a versatile new method that should enhance the discovery of new drugs and the study of proteins.

Insecticides mimic melatonin, creating higher risk for diabetes

Synthetic chemicals commonly found in insecticides and garden products bind to the receptors that govern our biological clocks researchers have found.

 Industry News   Show all: Industry News

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