The CanBiotech Newsletter:
Featuring News, Patient Engagement Blogs and Publications, Upcoming Events

 

 

Open-source approaches for the repurposing of existing or failed candidate drugs--Learning from and applying the lessons across diseases

Repurposing has the objective of targeting existing drugs and failed, abandoned, or yet-to-be-pursued clinical candidates to new disease areas. The open-source model permits for the sharing of data, resources, compounds, clinical molecules, small libraries, and screening platforms to cost-effectively advance old drugs and/or candidates into clinical re-development. Clearly, at the core of drug-repurposing activities is collaboration, in many cases progressing beyond the open sharing of resources, technology, and intellectual property, to the sharing of facilities and joint program development to foster drug-repurposing human-capacity development. A variety of initiatives under way for drug repurposing, including those targeting rare and neglected diseases, are discussed in this review and provide insight into the stakeholders engaged in drug-repurposing discovery, the models of collaboration used, the intellectual property-management policies crafted, and human capacity developed. In the case of neglected tropical diseases, it is suggested that the development of human capital be a central aspect of drug-repurposing programs. Open-source models can support human-capital development through collaborative data generation, open compound access, open and collaborative screening, preclinical and possibly clinical studies. Given the urgency of drug development for neglected tropical diseases, the review suggests elements from current repurposing programs be extended to the neglected tropical diseases arena.


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The CanBiotech Blog

Patient Engagement Strategy
Spotlight

Empowering Patients through Technology: Using a Chatbot to address health concerns

Through a collaboration with Verily and Google, Penn Medicine was able to leverage machine learning and natural language processing to develop and launch an interactive tool to help patients get answers to their questions. Read more...

Upcoming Events

Health Courses on edX
Future Pharma 2020
Future Pharma
Boston Marriott Long Wharf, Boston, MA
14/09/2020 - 15/09/2020
15th CTIP
15th Clinical Trials Innovation Programme
Tel Aviv, Israel
15/09/2020 - 16/09/2020
11th DDIP
11th Drug Discovery Innovation Programme
Tel Aviv, Israel
15/09/2020 - 16/09/2020
6th PSIP
6th Pharma Supply Chain & Logistics Innovation Programme
Basel, Switzerland
01/10/2020 - 02/10/2020
4th MDIP
4th Medical Devices Innovation Programme
Boston, MA
07/10/2020 - 08/10/2020
12th DDIP
12th Drug Discovery Innovation Programme
Boston, MA
07/10/2020 - 08/10/2020
16th CTIP
16th Clinical Trials Innovation Programme
Boston, MA
07/10/2020 - 08/10/2020
17th CTIP
17th Clinical Trials Innovation Programme
San Francisco, CA
21/10/2020 - 22/10/2020
5th MDIP
5th Medical Devices Innovation Programme an Francisco, CA
21/10/2020 - 22/10/2020
13th DDIP
13th Drug Discovery Innovation Programme
San Francisco, CA
21/10/2020 - 22/10/2020
18th CTIP
18th Clinical Trials Innovation Programme
Munich, Germany
16/11/2020 - 17/11/2020
14th DDIP
14th Drug Discovery Innovation Programme
Munich, Germany
16/11/2020 - 17/11/2020
7th PSIP
7th Pharma Supply Chain & Logistics Innovation Programme
Boston, MA
17/11/2020 - 18/11/2020
Pharmaceutical Compliance Congress Canada
Pharmaceutical Compliance Congress Canada
Montreal Airport Marriott Hotel, Montreal, Canada
17/11/2020 - 18/11/2020
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11th DDIP

11th Drug Discovery Innovation Programme Tel Aviv, Israel 15/09/2020 - 16/09/2020

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