Formulation development: Iinvolves studying the physico-chemical characteristics of the compound to establish a product that can be administered to patients in an safe and acceptable manner.

The objectives for the formulation development are to find a formulation that:

• Is pharmaceutically acceptable;
• Stabilizes the drug;
• Gives an appropriate manufacturing method for further development (Phase II trials etc.)

Chemical Synthesis: Full formulation development, stability studies and clinical trials require large quantities of material. The precise amount depends on the eventual doses used for the clinical trial. For the majority of drugs that enter the formulation unit, their synthesis has been carried out on a small scale. Large scale drug production involves establishing a synthetic method to produce grams or kilogram quantities of drug.

Formulation and Pharmaceutical Chemistry Services that can be outsourced on CanBiotech include:

Validation and Studies
  Analytical Validation
  Biological Analysis
  Chemical Analysis
  Dosage Form and Stability
  Manufacturing Validation Support
  Process Validation

Analytical
  Assay Development
  Chromatography
  ELISA Assay
  Electron Microscopy
  Electrophoresis
  FACS Analysis
  FISH Analysis
  Immunoassay
  IsoElectric Focus (IEF)
  Microarray
  Spectrometry
  Spectrophotometer Analysis
  X-Ray Crystallography


Chemistry
  Biochemistry
  Combinatorial Chemistry/Library Development
  Drug Synthesis
  Organic Chemical Synthesis