Drug Design: Includes not only ligand design, but also pharmacokinetics (pharmacogenomics) toxicity analysis. Nevertheless, appropriate chemometric (chemoinformatics) tools, including experimental design and multivariate statistics, can be of value in the planning and evaluation of pharmacokinetic and toxicological experiments and results.

Involves the molecular designing of drugs for specific purposes (such as DNA- binding, enzyme inhibition, anti- cancer efficacy) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules; An iterative process involving drug discovery, lead optimization and chemical synthesis with the aim of maximizing functional activity and minimizing adverse effects. 

Developability Studies: Preliminary in vivo experiments can assess the developability of discovery leads for human use. Positive results allow earlier and more cost-effective entry into clinical trials with well-designed, data-productive clinical protocols.

Studies should be conducted to determine if a discovery lead has the physical and chemical, as well as the biological, properties to be a drug candidate. These developability studies may also uncover concerns that must be resolved before beginning the definitive nonclinical studies needed to support an IND filing and before designing the clinical protocols, which will evaluate the candidate's safety and efficacy in humans.

Biopharmaceutical Development/Developability Research Services that can be outsourced on CanBiotech include:

Drug Development
  Discovery
  Efficacy Studies
  Formulation
  Screening
  Synthesis
  Toxicology Studies

Animal Services
  Animal Biotechnology
  Animal Management
  Feed Management
  Safety/Testing

Cell/Tissue Culture
  Blood and Serum Collection
  Cell Banking
  Cell Culture Production
  Cell Line Characterization
  Cell Sorting
  Immunohistochemistry Services
  Tissue Preparation
  Tissue Storage and Retrieval